β-catenin drives distinct transcriptional networks in proliferative and non-proliferative cardiomyocytes
نویسندگان
چکیده
منابع مشابه
Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development.
During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously generating daughters that contribute to the growing tissue. How tissues achieve this precise balance between proliferation and differentiation is, in most instances, poorly understood. This is in part due to the difficulties in dissociating the mechanisms that underlie tissue patterning from those tha...
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LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neuroblastomas. Neuroblastoma is a clinically heterogenous paediatric cancer comprising a high proportion of poor prognosis cases (~40%) which are frequent...
متن کاملLGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
Attiyeh EF, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nakagawara A. Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblas-toma cell line. of C-terminal deleted p53 isoforms in neuroblastoma. et al. NF1 is a tumor suppressor in neuroblasto...
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Background & objective: The current study aimed to perform an immunohistochemical analysis of patterns of apoptotic and cell proliferative related protein expression in different histological grades and immune phenotypes of malignant lymphomas and other lymphoproliferative disorders Methods:This observational study was carried o...
متن کاملProliferative and transcriptional identity of distinct classes of neural precursors in the mammalian olfactory epithelium.
Neural precursors in the developing olfactory epithelium (OE) give rise to three major neuronal classes - olfactory receptor (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons. Nevertheless, the molecular and proliferative identities of these precursors are largely unknown. We characterized two precursor classes in the olfactory epithelium (OE) shortly after it becomes...
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ژورنال
عنوان ژورنال: Development
سال: 2020
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.193417